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No Pediatric Research Equity Act (PREA) requirement has compelled Novo Nordisk to conduct trials in children aged 6 to 11 for this specific indication, though the company's ClinicalTrials.gov profile lists ongoing pediatric pharmacokinetic studies for semaglutide in younger populations

GI side effects (nausea, vomiting, diarrhoea) are dose-dependent

Studies in medial collateral ligament repair and segmental bone-defect models have reported earlier restoration of structural integrity, better-organised collagen architecture and accelerated callus formation effects consistent with enhanced local vascularisation

So to me, when people say, oh, supplements aren't regulated, I say actually they are regulated to some extent